Recognition that the mutations adversely impact regulation of RNA could lead to targeted therapy to correct the problem. The mutation’s location in the prion-like domain might also prove significant. Although the mutations in hnRNPA2B1 or hnRNPA1 appear to be rare, hundreds of other RNA-binding proteins have prion-like domains. Taylor said patients with unexplained neurodegenerative diseases may have mutations in these proteins.
Long-time fans of the Allman Brothers were saddened to learn Feb. 27 that former guitarist Dan Toler died at the age of 65. Dan and his brother David “Frankie” Toler, a drummer, were involved with a number of bands over the years, including the Allman Brothers from 1979 to 1982. Contact Music shared the details [...]