Posts belonging to Category Treatments

Mayo Clinic Researchers Place ALS Hope in Stem Cells

The trial is a safety study to determine if it’s safe to give ALS patients injections of stem cells grown from samples of their own fat tissue.

Final Results of ALS Phase I Stem Cell Trial Published in Annals of Neurology

The results showed that NSI-566 human spinal cord stem cells can be safely transplanted in both the lumbar and cervical spinal cord segments, did not accelerate disease progression, and warrant further study on dosing and therapeutic efficacy in ALS patients.

Study Shows Neuralstem Cells Transplanted Into Brain Significantly Improve Post-Stroke Symptoms in Rats

The researchers concluded that the NSI-566 cells are potent cell donors for transplantation therapy to treat paralysis in stroke patients

BrainStorm and Mass General Sign Definitive Agreement for ALS Clinical Trial

BrainStorm Cell Therapeutics, a leading developer of adult stem cell technologies for neurodegenerative diseases, announced today that it has signed a definitive agreement with the Massachusetts General Hospital (MGH) in Boston, MA to conduct a Phase II clinical trial of NurOwn™ in amyotrophic lateral sclerosis (ALS).

ALS Toxicity Reduced in Animal Models

In a new study published in Nature Genetics, University of Pennsylvania researchers and colleagues have made inroads into the mechanism by which ALS acts. Working with a powerful fruit fly model of the disease, they found a way of reducing disease toxicity that slows the dysfunction of neurons and showing that a parallel mechanism can reduce toxicity in mammalian cells. Their discoveries offer the possibility of a new strategy for treating ALS.

Biomarkers Help Predict Progress of ALS

While the size of this study is small, the ability of the specific biomarkers used to predict ALS prognosis suggests that the approach holds promise.

ALS Takes a Deep Breath with Diaphragmatic Pacing System

Traditionally, ALS patients like Mary would use a BiPAP machine to help her breathe. She’d wear a mask, tethered to a ventilator. It would force air into Mary’s lungs. Now, Mary is the first ALS patient at The Ohio State University to be implanted with a diaphragmatic pacing system to help her strengthen her muscles.

New Device Delays Ventilator Need for Some ALS Patients (Op-Ed)

For patients with amyotrophic lateral sclerosis (ALS), the simple act of breathing is often a tough thing to do. Now, these patients have new hope, as a device has been approved by the U.S. Food and Drug Administration (FDA) that may help patients to breathe more easily without a ventilator.

Diaphragm Pacing System Benefits Patients With ALS

Respiratory failure is one of the major complications associated with amyotrophic lateral sclerosis (ALS). The quest for alternative approaches for treating respiratory failure has led to the study, and subsequent FDA approval, of diaphragm pacing for use in ALS patients.

ImStar Selects Lead ALS Drug Candidate for Study by Mid-2014

“We are very excited to announce the selection of IMS-088 as ImStar’s lead ALS compound. As we continue with preclinical development next year, we hope to establish IMS-088 as a safe and effective new drug candidate for ALS,” said Jean-Pierre Julien, ImStar’s chief scientific officer.