AB Science SA, a pharmaceutical company specialized in research, development and marketing of protein kinase inhibitors (PKIs), announces, following the press release from November 4, that the acceleration of the clinical development program in ALS is in line with proof of efficacy experiments conducted in two different models that generated positive results of increased survival.
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Please join the Robert A. Stehlin Campaign for ALS (RASCALS) to “Fight ALS One Step At A Time”
on Saturday, Nov. 2nd, Tower Grove Park.
“We’re trying to prime the pump and fund (researchers) before they go into clinical trials,” said Melissa Forsythe, director of the Pentagon’s ALS Research Program. “Our goal every year is to make the very best investment we can.”
Researchers at Houston Methodist Neurological Institute and elsewhere will soon begin phase IIa clinical trials of TDI-132, a drug that in animal models has shown promise in reducing the inflammation associated with Amyotrophic Lateral Sclerosis, also known as ALS or Lou Gehrig’s Disease.
The Robert A. Stehlin Campaign for ALS (R.A.S.C.A.L.S.) is pleased to announce the election of Michael R. Brand to the foundation’s Board of Directors as Secretary, his duties include ensuring that board business is conducted in compliance with its bylaws, providing fiscal oversight, and maintaining a continuity of policies and practices in keeping with 501(c)(3) legal requirements.
Cytokinetics Inc. Announces Initiation of First-Time-in-Humans, Phase I Clinical Trial of CK-2127107
Cytokinetics, Incorporated announced today the initiation of a first-time-in-humans, Phase I clinical trial of CK-2127107 in healthy male volunteers. Cytokinetics is developing CK-2127107, a novel small molecule activator of the fast skeletal muscle troponin complex, for the potential improvement of skeletal muscle function in diseases and medical conditions associated with neuromuscular dysfunction, muscular weakness, and/or muscle fatigue. Like tirasemtiv, the lead drug candidate from the company’s skeletal muscle activator program, CK-2127107 slows the rate of calcium release from the regulatory troponin complex of fast skeletal muscle fibers, which sensitizes the sarcomere to calcium.
MDA has awarded a $400,000 grant to National Institutes of Health (NIH) Laboratory of Neurogenetics researchers to perform exome sequencing on samples taken from 1,000 people with sporadic amyotrophic lateral sclerosis (ALS). The project will be led by neurologist Bryan Traynor, head of the Neuromuscular Diseases Research Group at the NIH in Bethesda, Md.
This morning, Eric Nolet, general director of the ALS Foundation of the Netherlands, opened the trading day by sounding the bell to highlight World ALS Day — or Wereld ALS Dag.
Saneron will use the cells for future clinical trials to study possible therapies for restoring brain tissue in patients suffering from Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), also known as “Lou Gehrig’s disease,” and the effects of stroke.
St. Louis- Upon hearing about his diagnosis of amyotrophic lateral sclerosis (ALS) in September 2009, Bob Stehlin vowed to fight the disease with all his strength. He started the RASCALS Foundation to bolster medical and social service programs for others with the fatal neurodegenerative disease who live in Eastern Missouri as well as in Central [...]