According to Brian Kaspar, MD, a principal investigator in the Center for Gene Therapy at Nationwide Children’s and senior author of the new study, inhibiting NF-kB in microglia decreased ALS progression by 47 percent. “
“We are very excited to announce the selection of IMS-088 as ImStar’s lead ALS compound. As we continue with preclinical development next year, we hope to establish IMS-088 as a safe and effective new drug candidate for ALS,” said Jean-Pierre Julien, ImStar’s chief scientific officer.
According to a post hoc analysis, a greater percentage of patients receiving NP001 experienced a halt in disease progression which reached statistical significance when compared to the combination of concurrent and matched historical (placebo) controls. The high dose of NP001 (2mg/kg) halted progression in 27% of patients compared to 11% of patients on placebo. Further, NP001 was found to be safe and well-tolerated in the study.
The ALS Therapy Development Institute (ALS TDI), together with its wholly-owned subsidiary, Anelixis Therapeutics, announced today that it has formed a research partnership with Neurimmune to advance potential treatments for ALS, also known as Lou Gehrig’s disease.
University of Adelaide researchers have identified a likely molecular pathway that causes a group of untreatable neurodegenerative diseases, including Huntington’s disease and Lou Gehrig’s disease.
The group of about 20 diseases, which show overlapping symptoms that typically include nerve cell death, share a similar genetic mutation mechanism ? but how this form of mutation causes these [...]
The Robert A. Stehlin Campaign for ALS (R.A.S.C.A.L.S.) is delighted to welcome Sandra Putney to the foundation’s Board of Directors, where she will assume the duties of Treasurer. Sandra is committed to using her business acumen and leadership abilities to safeguard donor dollars while ensuring that donations are maximized for the organization’s mission.
The R.A.S.C.A.L.S. would like to acknowledge Greg Regan, who stepped down earlier this year from his post as Treasurer for the foundation. A member of the organization’s inaugural Board of Directors, Greg was instrumental in helping lay the groundwork for this charity’s signature events and educational efforts.
My heartfelt thanks goes out to all of you who helped to make the R.A.S.C.A.L.S. Second Annual 5K Walk/Run a resounding success.
2013 RASCALS 5K Official Results by Age Group and Overall Rankings.
AB Science SA, a pharmaceutical company specialized in research, development and marketing of protein kinase inhibitors (PKIs), announces, following the press release from November 4, that the acceleration of the clinical development program in ALS is in line with proof of efficacy experiments conducted in two different models that generated positive results of increased survival.