What Causes Lou Gehrig’s Sticky Masses?

Globs of protein clustered in the neurons that control muscles have long been the hallmark of amyotrophic lateral sclerosis (ALS), the fatal neurodegenerative disease also commonly known as Lou Gehrig’s disease. Now, a study of the most commonly found mutant gene in people with ALS reveals an unexpected origin of some of those sticky masses, a finding that may offer drug developers a new target for treatments.

ALS-FTD Research Briefs: P62 Gene’s Role and Screening Tool for ALS-FTD

Research news items on the role of the p62 gene in ALS-FTD and the ALS-FTD-Q, a new screening tool for assessing behavioral disturbances in ALS
By Amy Madsen, originally posted at MDA/ALS NewsMagazine, September 26, 2012
Article Highlights:

The finding that mutations in the p62 gene can cause frontotemporal lobar degeneration, added to an earlier finding that such [...]