Posted by Site Administrator on February 12, 2013
Globs of protein clustered in the neurons that control muscles have long been the hallmark of amyotrophic lateral sclerosis (ALS), the fatal neurodegenerative disease also commonly known as Lou Gehrig’s disease. Now, a study of the most commonly found mutant gene in people with ALS reveals an unexpected origin of some of those sticky masses, a finding that may offer drug developers a new target for treatments.
Categories: Research News, Treatments
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Tags: ALS, ALS community, ALS research, ALS research funding, ALS treatments, ALS-FTD, amyotrophic lateral sclerosis, Barrow Neurological Institute in Phoenix, Bob Stehlin, Bryan Traynor, C9ORF72 gene, C9orf72 mutations, Dieter Edbauer, dipeptide repeat (DPR) proteins, GGGGCC-laden C9orf72, Lou Gehrig's disease, Ludwig Maximilians University Munich in Germany, National Institute on Aging in Bethesda Maryland, neurodegenerative process ALS, PALS, protein clusters ALS, RASCALS Foundation, Robert A. Stehlin Campaign for ALS, St.Louis RASCALS ALS Lou Gehrig's Disease amotrophic lateral sclerosis, TDP-43, University of Antwerp in Belgium
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Posted by Site Administrator on October 19, 2012
Research news items on the role of the p62 gene in ALS-FTD and the ALS-FTD-Q, a new screening tool for assessing behavioral disturbances in ALS
By Amy Madsen, originally posted at MDA/ALS NewsMagazine, September 26, 2012
Article Highlights:
The finding that mutations in the p62 gene can cause frontotemporal lobar degeneration, added to an earlier finding that such [...]
Categories: Research News
| Tags: ALS, ALS community, ALS research, ALS treatments, ALS-FTD, ALS-FTD-Q, amyotrophic lateral sclerosis, autophagy., Bob Stehlin, charged multivesicular body protein 2B, CHMP2B), chromosome 9 open reading frame 72 (C9ORF72), Columbia University College of Physicians & Surgeons, common pathway, dysarthria, frontotemporal dementia FTD, frontotemporal lobar degeneration (FTLD), fused in sarcoma (FUS), Lewis P. Rowland, Lou Gehrig's disease, Methodist Neurological Institute, Northwestern University Chicago, optineurin (OPTN), P62 gene, P62 gene in ALS and FTLD, PALS, progranulin (PGRN, pseudobulbar affect, RASCALS Foundation, Rob J. DeHaan, Robert A. Stehlin Campaign for ALS, sequestosome 1, SQSTM1 gene, St.Louis RASCALS ALS Lou Gehrig’s Disease amotrophic lateral sclerosis, Stanley H. Appel, tar DNA binding protein 43 (TDP43), Teepu Siddique, ubiquilin 2 (UBQLN2), University of Amsterdam, valosin-containing protein (VCP)
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