Researchers at Emory University School of Medicine have demonstrated that this ALS/FTD mutation may be harmful because it creates an “RNA sponge,” soaking up an important regulatory protein that binds RNA.
Research news items on the role of the p62 gene in ALS-FTD and the ALS-FTD-Q, a new screening tool for assessing behavioral disturbances in ALS
By Amy Madsen, originally posted at MDA/ALS NewsMagazine, September 26, 2012
The finding that mutations in the p62 gene can cause frontotemporal lobar degeneration, added to an earlier finding that such [...]
The results suggest that certain networks in the brain might kick into overdrive to help maintain cognitive function in people with ALS over the course of the disease.
Researchers are hopeful after discovering a genetic mutation they think is responsible for the debilitating neurological disorder also known as amyotrophic lateral sclerosis (ALS). And they hope the findings might lead to a cure for another dreaded brain disease – dementia.
“Although clinically they have always been described as two separate diseases, they are overlapping. We now believe that ALS and FTD are actually different clinical manifestations of the same disease.”