Posted by Site Administrator on March 4, 2013
Recognition that the mutations adversely impact regulation of RNA could lead to targeted therapy to correct the problem. The mutation’s location in the prion-like domain might also prove significant. Although the mutations in hnRNPA2B1 or hnRNPA1 appear to be rare, hundreds of other RNA-binding proteins have prion-like domains. Taylor said patients with unexplained neurodegenerative diseases may have mutations in these proteins.
Categories: ALS News, Research News, Treatments
| 
Tags: Aaron Gitler, Alan Pestronk and Conrad Weihl, Aleksandra Wojtas, Alice Flynn Ford, ALS, ALS community, ALS research, ALS research funding, ALS study, ALS treatments, Amandine Molliex, amyotrophic lateral sclerosis, Anderson Kanagaraj, Athina-Soragia Gkazi, Bob Stehlin, Boston Biomedical Research Institute, Bradley Smith, Brian Freibaum, Bryan Traynor, Christopher Shaw, Colorado State University, Emily Scarborough, Eric Ross, exomes ALS, Germany, hnRNPA1, hnRNPA2B1, Hong Joo Kim, Institute of Psychiatry, J. Paul Taylor, Jack Miller, Jack Pinkus, Jennifer Moore, John Trojanowski, Kevin Boylan, Kyle MacLea, London, Lou Gehrig's disease, Mayo Clinic, Michael Benatar, Michael Kottlors and Janbernd Kirschner, Nam Chul Kim, National Institute of Aging, National Institutes of Health, neurodegenerative diseases, Oliver King, PALS, RASCALS Foundation, RNA metabolism ALS, Robert A. Stehlin Campaign for ALS, Robert Carter, Rosa Rademaker, Simon Topp, Songqing Li, St. Jude Children's Research Hospital, St. Jude Department of Developmental Neurobiology, St. Louis, St.Louis RASCALS ALS Lou Gehrig's Disease amotrophic lateral sclerosis, Stanford University School of Medicine, Steven Greenberg, University Children's Hospital Freiburg, University of California-Irvine, University of Miami Miller School of Medicine, University of Pennsylvania, Virginia Kimonis, Washington University Pediatric Cancer Genome Project, Washington University School of Medicine, Yun Li, Zamia Diaz
| 
No comments
Posted by Site Administrator on February 12, 2013
“This new finding sheds light on how the mutation causes these disorders, and it provides us with a marker that helps us track disease progression in patients with this disorder and potentially combat the disease,” says senior author Leonard Petrucelli, Ph.D., a molecular neuroscientist and director of the Department of Neuroscience at Mayo Clinic in Florida.
Categories: Research News, Technology, Treatments
| Tags: ALS community, ALS medical care, ALS research, ALS research funding, ALS treatments, amyotrophic lateral sclerosis, biomarker ALS, Bob Stehlin, C9ORF72 gene, C9RANT, Department of Neuroscience at Mayo Clinic Florida, DNA sequence ALS, frontotemporal dementia, Leonard Petrucelli, Lou Gehrig's disease, Mayo Clinic, motor neuron cells, Motor Neuron Disease, National Institutes of Health, neurodegenerative disorders, neuronal death and toxicity, PALS, RASCALS Foundation, Robert A. Stehlin Campaign for ALS, St.Louis RASCALS ALS Lou Gehrig's Disease amotrophic lateral sclerosis
| No comments
Posted by Site Administrator on October 1, 2012
Mayo Clinic is making strides in learning more about two deadly brain diseases, Lou Gehrig’s disease, known as ALS and a type of dementia.
Categories: Research News, Treatments
| Tags: ALS, ALS community, ALS gene discovery, ALS research, amyotrophic lateral sclerosis, Bob Stehlin, Dr. Rosa Rademakers, Lou Gehrig's disease, Mayo Clinic, RASCALS Foundation, Robert A. Stehlin Campaign for ALS, St.Louis RASCALS ALS Lou Gehrig’s Disease amotrophic lateral sclerosis
| No comments
Posted by Site Administrator on May 15, 2012
What are other diseases or conditions that mimic ALS?
Categories: Caretakers, Research News
| Tags: ALS, ALS community, ALS diagnostics, ALS mimics disease, ALS research, Alzheimer's disease, amyotrophic lateral sclerosis, Amyotrophic Lateral Sclerosis Fact Sheet, diagnosing ALS, disease mechanism of action, Lou Gehrig's disease, Mayo Clinic, Medline Plus, Motor Neuron Disease Fact Sheet, Multiple Sclerosis, National Institute of Neurological Disorders and Stroke, Parkinson's disease, PLS, Post-polio syndrome, PPS, Primary lateral sclerosis, Progressive bulbar palsy, Progressive Muscular Atrophy, Pseudobulbar Palsy, RASCALS Foundation, Robert A. Stehlin Campaign for ALS, SMA, Spinal Muscular Atrophy, St.Louis RASCALS ALS Lou Gehrig's Disease amotrophic lateral sclerosis
| No comments
Posted by Site Administrator on January 13, 2012
Researchers are hopeful after discovering a genetic mutation they think is responsible for the debilitating neurological disorder also known as amyotrophic lateral sclerosis (ALS). And they hope the findings might lead to a cure for another dreaded brain disease – dementia.
Categories: Research News
| Tags: ALS, ALS community, ALS research, amyotrophic lateral sclerosis, Dr. Adam Boxer, Dr. Brian Traynor, Dr. Rosa Rademakers, frontotemporal dementia FTD, Lou Gehrig's disease, Mayo Clinic, National Institutes of Health, RASCALS Foundation, Robert A. Stehlin Campaign for ALS, St.Louis RASCALS ALS Lou Gehrig's Disease amotrophic lateral sclerosis, University of California at San Francisco
| No comments
Posted by Site Administrator on January 13, 2012
“Although clinically they have always been described as two separate diseases, they are overlapping. We now believe that ALS and FTD are actually different clinical manifestations of the same disease.”
Categories: Research News
| Tags: ALS, ALS Association, ALS community, ALS research, amyotrophic lateral sclerosis, C9ORF72, chromosome 9, Dr. Bryan Traynor, frontotemporal dementia, frontotemporal dementia FTD, FTD, Lou Gehrig's disease, Lucie Bruijn, Mayo Clinic, Neuromuscular Diseases Research Group, RASCALS Foundation, Robert A. Stehlin Campaign for ALS, U.S. National Institutes of Health
| No comments
