New Therapeutic Target Identified for ALS

Scientists have identified a novel therapeutic approach for the most frequent genetic cause of Amyotrophic lateral sclerosis (ALS).

RASCALS Salutes Greg Reagan

The R.A.S.C.A.L.S. would like to acknowledge Greg Regan, who stepped down earlier this year from his post as Treasurer for the foundation. A member of the organization’s inaugural Board of Directors, Greg was instrumental in helping lay the groundwork for this charity’s signature events and educational efforts.

Thank You For Helping Us Take Another Step Forward in the Fight Against ALS

My heartfelt thanks goes out to all of you who helped to make the R.A.S.C.A.L.S. Second Annual 5K Walk/Run a resounding success.

2013 RASCALS 5K Official Results

2013 RASCALS 5K Official Results by Age Group and Overall Rankings.

Acceleration of Clinical Program in ALS Confirms Proof of Efficacy Data Obtained in Animals

AB Science SA, a pharmaceutical company specialized in research, development and marketing of protein kinase inhibitors (PKIs), announces, following the press release from November 4, that the acceleration of the clinical development program in ALS is in line with proof of efficacy experiments conducted in two different models that generated positive results of increased survival.

Macomb County Woman Pens Book about Father’s Struggle with ALS

Dr. Julie A. Rouse’s father, Jerome “Jerry” Kowalski, was diagnosed with Amyotrophic Lateral Sclerosis in 2003. She said she struggled to find any information to help her understand the disease or what her family would face as it progressed.

Lab Researches Neuromuscular Disease

The research is based around the importance of a protein called Brain-Derived Neurotropic Factor (BDFN) in the development of pathology. BDFN is produced in both neurons and muscles, carrying signals between those two parts of the motor unit—communication that is critical to proper functioning of the muscle, Ottem said.

November is National Caregivers Month

A caregiver is a person who gives of oneself, tirelessly, endlessly, with love and support to another who is struggling and suffering.
The RASCALS Foundation salutes all the world’s selfless caregivers. My personal salute is to my dear wife Laura for her care and comfort she provides to me every minute of the day. — RASCALS Founder, Robert A. Stehlin

Last Day to Pre-Register for the RASCALS Foundation 5K Walk/Run in Tower Grove Park, November 2nd

Please join the Robert A. Stehlin Campaign for ALS (RASCALS) to “Fight ALS One Step At A Time”
on Saturday, Nov. 2nd, Tower Grove Park.

Lou Gehrig’s Disease: From Patient Stem Cells to Potential Treatment Strategy in One Study

“In these studies, we turned skin cells of patients who have ALS into motor neurons that retained the genetic defects of the disease,” Baloh said. “We focused on a gene, C9ORF72, that two years ago was found to be the most common cause of familial ALS and frontotemporal lobar degeneration, and even causes some cases of Alzheimer’s and Parkinson’s disease. What we needed to know, however, was how the defect triggered the disease so we could find a way to treat it.”